How Cannabis Might Keep Coronary Stents Open Longer

By David B. Allen M.D.
Cardiothoracic and Vascular Surgeon, Member ICRS.
And Prisoner of the Drug War Cali215doc@gmail.com

First the set up information; (Scientific information translated to human-speak)

Vascular Stent

It has been proven by several independent studies that Cannabinoids inhibit a type of brain tumor called a Glioma. Gliomas comprise up to 77% of all brain  tumors.

The majority of them are quite malignant causing death in a matter of months after diagnosis. Cannabinoids inhibit these tumors by inhibiting a hormone like substance called VEGF (Vascular Endothelial Growth Factor).

VEGF is a signaling protein produced  by your body and in some cases these tumors take advantage of this signaling system to redirect blood flow to the tumor itself. Your body normally produces VEGF in response to hypoxia (low oxygen) or from damage to the inner lining of the blood vessel. (The Intima). VEGF does 2 things;

  1. VEGF causes new blood vessels to grow into an area that secretes this signaling protein.

(This is called vasculogenesis or angiogenesis, and is what the tumor takes advantage of.)

  • VEGF causes the cells that form the inner lining of the vessel (Intima or endothelium) to multiply and cover or repair damaged areas of the blood vessel.

VEGF can be secreted by Malignant Gliomas and this causes blood vessels to grow into the tumor. This new blood supply then helps the tumor grow by providing blood, oxygen and nutrition to it. Cannabinoids inhibit VEGF and thus stop in growth of blood vessels into the tumor and thus inhibit tumor growth.  Cannabinoids  can actually kill Gliomas by this mechanism. (This is the tumor that Senator Edward Kennedy died from.)

VEGF also plays a significant role in restenosis of coro- nary arteries. VEGF is involved in the repair process of arteries. VEGF causes the cells that line the inner wall of the vessels (the endothelial cells) to proliferate and cover any damaged area of the vessel wall.

During a heart attack, the narrowed or blocked coro- nary arteries restrict blood, oxygen and nutrients from meeting the metabolic demand of the heart muscle. This reduced oxygen supply to the muscle causes some of the muscle to die. Only opening the artery with balloon angioplasty/stent or coronary bypass with correct the situation, and restore blood and oxygen to the heart.

Angioplasty

Coronary artery stent placement

Whenever a cardiologist opens a coronary artery by balloon angioplasty and stent, there is damage to the inner- lining of the artery. Although the newly opened artery is now supplying increased blood flow to the muscle, there are multiple cracks in the inner lining of the vessel. After the stent placement, the body immediately begins a repair process to heal the injured vessel. It does this by Vascular Endothelial Proliferation. The vessels inner wall cells (Intima or endothelium) multiply and cover raw areas of the damaged artery. Sometimes the repair mechanism works too well, and when VEGF is over expressed it can contribute to disease.

When VEGF is over expressed it causes the intimal cells to proliferate so much the cells overmulitply and cause restenosis or occlusion of the newly opened artery.

Restenosis or occlusion of an opened artery is a constant problem for the cardiologist and patient. Many medica- tions are currently given to prevent stent restenosis.

If THC and Cannabidiol both inhibit VEGF, and this slow or stops Glioma tumor growth; Is it possible, that by this same mechanism it could prevent coronary stent restenosis? This is a very plausible theory to examine. Unfortunately, in the United States there is a virtual ban on scientific research on cannabis. Why would there be a ban on such knowledge?

Additionally the newer stents are coated with “medica- tion” to prevent an over active repair mechanism from causing harm. These “Drug Eluting  Stents”  slowly  leak  out this medication to slow the Vascular Endothelial Proliferation. This limits the proliferation of the endothe- lial repair cells and thus keeps the stent open longer.

If THC and Cannabidiol both inhibit VEGF, and this slow or stops Glioma tumor growth; Is it possible, that by this same mechanism it could prevent coronary stent resteno- sis? This is a very plausible theory to examine. Unfortunately, in the United States there is a virtual ban on scientific research on cannabis. Why would there be a ban on such knowledge? Is there danger to the public if scientific research were to be done under controlled con- ditions? Is it just too much risk that a little pot might be diverted from the study and become a supply route for the pot smokers of America? (Please excuse the heavy sar- casm.) Is the benefit of finding a cure for cancer or for coronary restenosis enough to subject patients to this risk? These same risk/benefit questions are asked about cannabis effect on hundreds of human ailments.

I suspect that many Americans would volunteer for a study that examined cannabis as a substance that could potentially keep coronary stents open longer or possibly treat your brother’s brain tumor.  I believe the public would accept this as a justified risk, as the potential bene- fits are enormous.

As mentioned in my prior articles the Government has a patent on Cannabinoids as Antioxidants and Neruoprotectants (patent number 6630507). This patent and study shows that lab animals had 50% reduction in the size of a stroke when given Cannabidiol or THC. Another study in the British Journal of pharmacology entitled “Acute administration of Cannabidiol in vivo suppresses ischemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.” This study also shows that heart attack size (infarct size) is dimin- ished by near 50% and abnormal rhythms of the heart are inhibited. This occurred even if Cannabidiol was given after the heart attack had begun. So there is evidence that strokes and heart attacks can be limited in their destruc- tive effect by a safe medication that happens to be mis- scheduled as a danger to the public.

Recently, a government spokesperson stated that the gov- ernment was not intentionally limiting scientific study on

cannabis. This lie contradicts previous position statements made by multiple officials who have repeatedly stated; “We are not in the business of proving Marijuana’s med- ical benefit and only studies proving harm are approved for research.” No reversal of this position  on prohibition of scientific study of marijuana has been released. (This would be an admission of guilt.) Currently no studies are approved in these or other medical applications of Cannabis. Would the government intentionally prevent its citizens from receiving a life saving medication for politi- cal reasons? Would the profits from arresting 850,000 cit- izens a year have any effect on their decision?

I wish that Ted Kennedy had received this medicine. Ted was having seizures and could have benefited from cannabis ability to reduce seizure activity.  Only  God knows if Ted Kennedy’s Glioma would have responded to cannabis. Eventually the Government will concede that Cannabis Is Medicine. I pray that I will see that day.

REFERENCES

  1. Inhibition of Tumor Angiogenesis by Cannabinoids; FASEB Journal 2003; 17; 529-531
  2. Delta 9 tetrahydorcannabinol increases C6 Glioma cell death produced by oxidative stress Original Research Article, Neuroscience; Vol 134, Issue 2, 2005 pp 567-574 Vogel et al.
  3. Antitumor Effect of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines. Paola Massi, Et al; Journal of Pharmacology and Experimental Therapeutics December, 2011 (339)
  4. Cannabinoids as antioxidants and neruoprotectants; US Patent 6630507 Oct. 7, 2003 US Dept of Health and Human Services
  5. Acute Administration of Cannabidiol in vivo suppresses ischemia-induced car- diac arrhythmias and reduces infarct size when given at reperfusion. British

Journal of Pharmacology July, 2010, 160 (5): 1234-1242


Leave a Reply

Your email address will not be published. Required fields are marked *

Latest Posts

This menu shows the most recently posted content for a quick update since you last checked-in.

How to Make Your Own Canna-Caps

by Old Hippie BeyondChronic.com What do you do when you need cannabis medicine and you can’t or don’t want to...

Database Search

Are you researching marijuana as medicine? Use the simple form below to search any condition. Read personal stories from patients just...

Cannabinoid Receptors in the Body and Their Importance

David B. Allen M.D. By legal Democratic Vote; Cannabis Is Medicine In 1964 Raphael Macheoulam, an Israeli professor of Medicinal...

The True Origins of Haze

By Big Herb It all began in 1969, In Santa Cruz, California. At the time, there was Thai Oaxacan and...

Top 5 Health Benefits of Hemp Seeds

Hemp seeds are those seeds that are formed from Cannabis Sativa, a hemp plant. They are different from marijuana but...

Cannabis and Working Out

If you're wondering how cannabis can help you with your workout regime, then you probably need to read this article....

How Companies Are Creating Innovative New CBD Products

Cannabidiol (CBD) is a non-psychoactive compound found in cannabis and hemp that may deliver unique health benefits. CBD is just...

5 Marijuana Compounds That Could Help Combat Cancer, Alzheimer’s & Parkinson’s

by Paul Armentano Deputy Director of NORML (the National Organization for the Reform of Marijuana Laws) This commentary was initially...

Living with Osteogenesis Imperfecta

By Michael Morrow My name is Michael Morrow, I'm 37  years  old and I have Osteogenesis Imperfecta. OI is a...

Gifts from Mother Nature

By Dianna Donnelly - "The couch activist” Aspirin, otherwise known as Acetylsalicylic Acid, is one of the most commonly ingested preventative medicines...

Paradise Seeds Allkush; More Than Just Kush

One of the new feminised strains from Paradise Seeds is named “Allkush”. So nothing but Kush? Taken genetically literally, no...

28ft… The John Berfelo Story

By John Berfelo "Medical marijuana saved me from a life on pharmaceutical drugs..." My name is John Berfelo and this...

My Grinspoon Moment

By Carl Hedberg Sometimes a single meeting can change your life. Such was the case for me when, in the...

The Science Behind Cannabis Safety

David B. Allen M.D. By legal Democratic Vote; Cannabis Is Medicine. Drug safety is on the minds of most all...

Heavenly Hash: The Art, Science and Industry of Cooking with Cannabis Extracts

by Samuel Wells Samuel Wells is an Assistant Professor of English in Denver, CO An Edible Enigma As scientific and...

Living High with HIV

How Medical Marijuana Rivals Mainstream HIV Medicine By BenBot In 2011, I was diagnosed with HIV. An unmarked van was...

Post-Traumatic Stress Disorder

With Veterans at Risk, Change is Necessary, but Progress is Slow By Mary Lou Smart In 1933, the repeal of...

Milagro Oil for Lung Cancer

By Mary Lou Smart www.medicalcannabisart.com Compassionate care advocates Michelle and Michael Aldrich at Patients Out of Time’s Seventh National Clinical...

Living and Dealing with ADHD

by Patricia Allen It was back in 1974 that I first became familiar with the term Attention Deficit Hyperactivity Disorder...

Inflammatory Comments

by Bill Drake As a long-time TY reader I’ve noticed what seems to me to be a rather over- whelming...

How Cannabis Might Keep Coronary Stents Open Longer

By David B. Allen M.D.Cardiothoracic and Vascular Surgeon, Member ICRS. And Prisoner of the Drug War Cali215doc@gmail.com First the set...

Unlocking the Secrets, Advanced Tissue Culture

Tissue Culture is a process of isolating cells from plant tissue (explants) which are cultured (grown artificially), in a nutrient...

Anxiety Panic Disorder and Cannabis

By Hal Lubinsky My name is Hal Lubinsky. I'm in my forties, a husband, a father, a grandfather, a U.S....

Can Cannabis Cure Schizophrenia?

By Richard Shrubb, Freelance sailing, health and social affairs journalist ould cannabis treat or even cure schizophrenia? Things look promising...

Multiple Sclerosis: Regaining the Good Life with Whole Plant Therapy

By Mary Lou Smart© 2012 www.medicalcannabisart.com A trial attorney, Jim Dyer practiced law in Tucson, Arizona for 34 years before...

The Science of Cannabis Leads in Many Directions

The Evolution of a Sense of Well-Being By Mary Lou Smart www.medicalcannabisart.com While speaking at Patients Out of Time’s Seventh...

Healthy Body, Healthy Mind

By Shantibaba It is evident for all people who wish to listen that doing all things within moderation is better...

Post Traumatic Stress

Psychology and Medication at its Best By Jeff Kundert OTR Jeff works as a Wellness and Fitness Educator. He has...

The Ripper Effect

By Subcool Some really interesting information has come to my attention, and I am very excited to tell everyone in...

Auto-flowering Plants

By Shantibaba The discreet evolution of Auto-flowering cannabis plants is a recent occurrence, one that is in mode at present...

Uncovering the Original Sacrament: Chris Bennett’s Cannabis and the Soma Solution

Review by Samuel Wells When asked to name an author crucial to the growing mainstream understanding of the uses of...

Storm’s Story

By Georgia Peschel WHEW! Delivering this kid was like delivering a hurricane!” When our son was born, those were our...

Soil Pests & Diseases

By Lazystrain Soil is a living organism made up of billions of microbes and bacteria. The cosmology of soil life...

Autism & Cannabis

Prohibition Makes it Tough on Parents by Mary Lou Smart Jeremy Patrone (not his real name) has a goal. He...

Vaporization of Cannabis: Are there benefits over combustion?

By William Eckhardt Although vaporization is a relatively recent development for the delivery of cannabinoids the proliferation of vast numbers...

Bedrocan

By Harry Resin Generally when you think of Amsterdam, you think of the coffee shops, but that’s not all that’s...

Why Get Pines Wheatgrass

Wheatgrass might just be a typical plant growing in your backyard, but few people know that it has a lot...

What the Ding-Dong Is Decarboxylation?

by Old Hippie BeyondChronic.com Decarboxylation: Why you never heard of it, why you should understand it, and how to do...

Cannabis for Seniors, their Doctors & Caregivers

By Old Hippie BeyondChronic.com While this article is entitled Cannabis for Seniors, its intent is to inform and reassure new...

For Surface Issues, Cannabis Lotions Hit the Spot

by Mary Lou Smart www.medicalcannabisart.com In the late 1800s and early 1900s, topicals and extracts containing cannabis were all the...